Polygonum Multiflorum

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14.95 USD
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Biotanica, Polygonum Multiflorum (Heshouwu), Premium Herbal Extract
  • Replenishes Energy*
  • Supports Healthy Blood*
  • Longevity & Youth Tonic*
  • Boosts Libido*


Soy Free

Cruelty Free

Egg Free

Wheat Free

Dairy Free

Meat Free

100% Natural

Gluten Free

NZ Packed

Recyclable
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14.95 USD

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Soy Free

Cruelty Free

Egg Free

Wheat Free

Dairy Free

Meat Free

100% Natural

Gluten Free

NZ Packed

Recyclable
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Soy Free

Cruelty Free

Egg Free

Wheat Free

Dairy Free

Meat Free

100% Natural

Gluten Free

NZ Packed

Recyclable
Low Price Guarantee
Found a lower price?
We'll beat it.
Fast, Free Shipping *
Orders shipped within
2 business days.
Free ship over 79 USD
Customer Support
Ambassadors standing
by 7 days a week.
90 Day Returns
Money back options! Don't
like it? Simply send it back!

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Product Description
Our Premium Polygonum Multiflorum (Heshouwu) supplement is standardized to 10% Tetrahydroxystilbene Glucosides extract. Polygonum Multiflorum is known by several names such as Heshouwu, Fo-ti, Shou-Wu-Pian, Shen-Min, Tuber fleece flower, and Chinese knotweed. Besides the traditional use of folk tonics, extracts of Polygonum multiflorum have been shown to support healthy aging [1]. 2,3,5,4-Tetrahydroxystilbene-2-O-l-D-glucoside, isolated from Polygonum multiflorum, which is traditionally used as a healthy aging support tonic. Tetrahydroxystilbene glucoside possesses a potent antioxidative capacity, it may enhance stress resistance supporting healthy aging. *
Product Benefits
Mounting studies have stressed out its key benefit for the support of various health benefits such as liver health, blood sugar management, healthy hair and brain health. The leaves, root tuber and rhizomes of this plant have been used as healthy age support whereas the stem is used as a useful sleep aid [15]. *
This tonic herb might be useful for supporting a healthy reproductive system, boosting vitality, bowel movements, kidney healthy, urinary health, menstrual support, blood pressure management, healthy cholesterol levels, lean muscle support, healthy tendons and bones, a sleep aid and hearing health [2,3,4]. *

Ageing is defined as an accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that is responsible for the increased risk of health issues. Extracts of Polygonum multiflorum are used as a healthy aging support tonic in East Asian countries [5]. Research suggests this could be related to the 2,3,5,4-tetrahydroxystilbene-2-O-l-D-glucoside, the main bioactive component of Polygonum multiflorum. It is a potent antioxidant and it has significant oxidant stress decreasing property [6]. Physcion, apigenin, hyperoside, rutin, vitexin, beta-amyrin, beta-sitosterol, and daucosterol are other compounds which may provide antioxidant support. *
In traditional Chinese remedies, preparations from Polygonum multiflorum have a long history of use for hair growth and blackening. Both oral and topical administration of P. multiflorum preparations were used for hair graying sometimes simultaneously in traditional application methods. The hair growth promotion effect of oral Polygonum multiflorum was most likely mediated by the expression of fibroblast growth factor-7 [7]. After 1 month of taking extracts of P. multiflorum twice daily, 91% of men and 87% of women reported improvement. Additionally, none of the study participants reported any side effects during the treatment period [7]. *
Steele et al. [8] reported cell protective effects of an extract of Polygonum multiflorum in astroglial cells (brain and spinal cells). An improvement of cognitive performance and reduction in glutamate-induced neurotoxicity [9] were observed. 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside has been shown to exert positive effects on learning and memory in animal models. *
Colitis, a bowel challenge that causes disruption of the digestive tract. 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside of Polygonum multiflorum exerts protective effects on experimental digestive health through alleviating oxygen and nitrogen free radicals level and down-regulating inducible nitric oxide synthase expression [10]. *
Wang et al. [11] showed that 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside has blood flow effects for cerebral ischemia (an inadequate blood supply to the brain). It also mediates antagonistic effects on oxidation of lipoprotein, proliferation, and a decrease of nitric oxide content of coronary arterial smooth muscle cells, which explains the anti-atherosclerosis mechanism of Polygonum multiflorum [12]. *
Polygonum multiflorum a novel natural inhibitor of advanced glycation ends product formation which plays a major pathogenic role in blood sugar health and its complications [13]. *
Sun et al. [14] showed that tetrahydroxystilbene glucoside protects human from neurodegenerative disorders. It can inhibit the 1-methyl-4-phenylpyridinium (a neurotoxin that causes cell death) action and improve the mitochondrial function, decrease oxidative stress and inhibit apoptosis which may be relevant for healthy brain cognition. *
Laboratory studies and clinical practice have demonstrated that Polygonum multiflorum possesses various biological and health benefits, healthy cell growth [16], bacteria support [17], cell-calming [18], virus support [19]. *
The reports and research on the hepatotoxicity of Polygonum multiflorum and its preparations have multiplied. The China (CFDA) has limited the dose of raw Polygonum multiflorum to 1.5 g/day and processed Polygonum multiflorum to 3.0 g/day and added subjects with Liver health, family history of liver challenges as unsuitable for the use of healthy food that contains Polygonum multiflorum [20]. *
Nutritional Profile
2,3,5,4-Tetrahydroxystilbene-2-O-l-D-glucoside is the active ingredients of Polygonum multiflorum. The other compounds include emodin, emodin glucopyranoside, emodin dianthrones (trans-emodin dianthrones and cis-emodin dianthrones), and polygonumnolides. Physcion, apigenin, hyperoside, rutin, vitexin, beta-amyrin, beta-sitosterol, and daucosterol also rich in Polygonum multiflorum.
Suggested Use
Take 250 - 300mg of our extract daily.
Interactions & Warnings
Always consult with your doctor or health professional before changing your health regime.
Shelf Life
2 Years from Date of Manufacture.
Storage
Use a sealed container to store this product in a cool, dry place. Keep away from direct light and moisture. Once the package is opened, it must be re-sealed and used within 6 months.
References
 
  1. Büchter C, Zhao L, Havermann S, et al. TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans . Oxidative and Cellular Longevity. 2015;2015:124357. doi:10.1155/2015/124357
  2. Lin, Longfei; Ni, Boran; Lin, Hongmei; Zhang, Miao; etc. (15 January 2015). "Traditional usages, botany, phytochemistry, and toxicology of Polygonum multiflorum Thunb.: A review". Journal of Ethnopharmacology. 159: 158–183.
  3. Polygonum multiflorum and liver reactions". MHRA. 2006. Archived from the original on 2014-12-05.
  4. Lin, Longfei; Ni, Boran; Lin, Hongmei; Zhang, Miao; etc. (15 January 2015). "Traditional usages, botany, phytochemistry, and toxicology of Polygonum multiflorum Thunb.: A review". Journal of Ethnopharmacology. 159: 158–183.
  5. Beneficial effects of different Polygonum multiflorum Thunb. extracts on memory and hippocampus morphology. Chan YC, Cheng FC, Wang MF J Nutr Sci Vitaminol (Tokyo). 2002 Dec; 48(6):491-7.
  6. Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. Sun FL, Zhang L, Zhang RY, Li L Eur J Pharmacol. 2011 Jun 25; 660(2-3):283-90.
  7. Han M-N, Lu J-M, Zhang G-Y, Yu J, Zhao R-H. Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying. BioMed Research International. 2015;2015:651048. doi:10.1155/2015/651048.
  8. Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells.Steele ML, Truong J, Govindaraghavan S, Ooi L, Sucher NJ, Münch G Neurochem Int. 2013 Apr; 62(5):522-9.
  9. Hexane extract from Polygonum multiflorum attenuates glutamate-induced apoptosis in primary cultured cortical neurons.Jang JY, Kim HN, Kim YR, Choi YW, Choi YH, Lee JH, Shin HK, Choi BTJ Ethnopharmacol. 2013 Jan 9; 145(1):261-8. 10. Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. Wang X, Zhao L, Han T, Chen S, Wang JEur J Pharmacol. 2008 Jan 14; 578(2-3):339-48.
  10. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Wang T, Gu J, Wu PF, Wang F, Xiong Z, Yang YJ, Wu WN, Dong LD, Chen JG Free Radic Biol Med. 2009 Aug 1; 47(3):229-40.
  11. Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside on lipoprotein oxidation and proliferation of coronary arterial smooth cells. Liu QL, Xiao JH, Ma R, Ban Y, Wang JL J Asian Nat Prod Res. 2007 Sep-Dec; 9(6-8):689-97.
  12. Stilbene glucoside from Polygonum multiflorum Thunb.: a novel natural inhibitor of advanced glycation end product formation by trapping of methylglyoxal. Lv L, Shao X, Wang L, Huang D, Ho CT, Sang SJ Agric Food Chem. 2010 Feb 24; 58(4):2239-45.
  13. Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.Sun FL, Zhang L, Zhang RY, Li LEur J Pharmacol. 2011 Jun 25; 660(2-3):283-90.
  14. Bounda G-A, Feng Y. Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds. Pharmacognosy Research. 2015;7(3):225-236. doi:10.4103/0974-8490.157957.
  15. Choi SG, Kim J, Sung ND, Son KH, Cheon HG, Kim KR, et al. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. Nat Prod Res. 2007;21:487–93.
  16. Zuo GY, Wang GC, Zhao YB, Xu GL, Hao XY, Han J, et al. Screening of Chinese medicinal plants for inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) J Ethnopharmacol. 2008;120:287–90.
  17. Cha DS, Jeon H. Anti-inflammatory effect of MeOH extracts of the stem of Polygonum multiflorum in LPS-stimulated mouse peritoneal macrophages. Nat Prod Sci. 2009;15:83–9.
  18. Lin HW, Sun MX, Wang YH, Yang LM, Yang YR, Huang N, et al. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med. 2010;76:889–
  19. Lin L, Li H, Lin H, et al. A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor. Frontiers in Pharmacology. 2017;8:349. doi:10.3389/fphar.2017.00349.
 
Disclaimer
While Biotanica® strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally ship with alternate packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by Biotanica® or any other health advice, information or independent product reviews.
Supplement Facts
Serving Size:
TAKE 250 - 300mg DAILY.
Amount Per Serving
% Daily Value
POLYGONUM MULTIFORA 10% TETRAHYDROXYSTILBENE GLUCOSIDE EXTRACT.
250 - 300mg mg
**
** Daily value not established.
Customer Reviews
4.44
16
5 Stars
62%
(10)
4 Stars
18%
(3)
3 Stars
18%
(3)
2 Stars
0%
(0)
1 Star
0%
(0)
Disclaimer: Product reviews solely reflect the views and opinions expressed by the contributors and not those of Biotanica®


Biotanica® Customer
The Best
Posted by Biotanica® Customer on September 28 2018 | Verified Purchase
Really helps
Jamal
Could not live without it!
Posted by Jamal on August 10 2018 | Verified Purchase
good as usual.
Biotanica® Customer
Great stuff!
Posted by Biotanica® Customer on August 07 2018 | Verified Purchase
Arrived on time
Biotanica® Customer
The Best
Posted by Biotanica® Customer on July 17 2018 | Verified Purchase
Arrived on time
Biotanica® Customer
Very helpful product
Posted by Biotanica® Customer on June 26 2018 | Verified Purchase
Good and effective
Biotanica® Customer
Helpful? Not Convinced
Posted by Biotanica® Customer on June 03 2018 | Verified Purchase
too early to tell
Biotanica® Customer
Easy to take
Posted by Biotanica® Customer on May 28 2018 | Verified Purchase
Working well for me and am thankful.
Biotanica® Customer
Fo-Ti
Posted by Biotanica® Customer on May 12 2018 | Verified Purchase
Helped slow down frontal hair loss.
Biotanica® Customer
Great stuff!
Posted by Biotanica® Customer on May 05 2018 | Verified Purchase
good value.
Dawson
Darker hair
Posted by Dawson on April 18 2018 | Verified Purchase
Apparently this can darken grey hair. I've noticed my hair feels fuller and i swear there's less grey hair.
Haiden
It Was A Good Product
Posted by Haiden on February 27 2018 | Verified Purchase
Good and effective
Jade
Not sure it is good
Posted by Jade on February 23 2018 | Verified Purchase
Arrived late.
Brynn S.
No Difference
Posted by Brynn S. on January 25 2018 | Verified Purchase
slow delivery
Biotanica® Customer
Highly Recommend
Posted by Biotanica® Customer on January 22 2018 | Verified Purchase
Have already repurchased.
Heather
Awesome Products!
Posted by Heather on January 20 2018 | Verified Purchase
very solid products great price for great product
Biotanica® Customer
an excellent product
Posted by Biotanica® Customer on January 15 2018 | Verified Purchase
really great value for money and arrived quickly!




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